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Tetracalcium Phosphate

Tetracalcium phosphate is an inorganic compound that is one of the several calcium phosphate compounds. It is also known by its other names, such as tetracalcium diphosphate oxide, TTCP (tetracalcium phosphate), and calcium phosphate tetraoxide. This compound is of interest in various fields, including dentistry and orthopedics, due to its applications in biomaterials and bone regeneration.
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About Tetracalcium Phosphate:

Molecular Weight: Approximately 502.31 g/mol

Appearance: Typically a white powder.

Solubility: Tetracalcium phosphate is relatively insoluble in water, which is a characteristic trait of many calcium phosphate compounds. This low solubility is beneficial for applications that require gradual degradation or dissolution in biological environments.


Applications of Tetracalcium Phosphate:

Pharmaceutical Industry:

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Bone Grafting Materials: TTCP is extensively used in the formulation of synthetic bone graft materials. When combined with other calcium phosphates, such as dicalcium phosphate (DCP), it can form a composite material that closely mimics the mineral component of natural bone. These composites can be used to fill bone defects or augment bone in areas where natural bone growth needs assistance. 

Orthopedic Implants: A coating of TTCP on metal implants can improve the integration of the implant with the surrounding bone tissue, enhancing the stability and longevity of the implant. 

Drug Delivery Systems: Tetracalcium phosphate has been explored as a carrier for drug delivery systems, especially for the localized delivery of bone-regenerative drugs, antibiotics, or anti-inflammatory agents. tp5

Regenerative Dentistry: TTCP can release calcium and phosphate ions, which are essential for remineralization processes in the tooth structure, thereby aiding in the prevention of cavities and the treatment of tooth sensitivity.

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Cosmetic Industry: Tetracalcium phosphate could serves as an additive in some toothpaste formulations. 

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